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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Orthop Res. 2011 Mar 28;29(9):1367–1374. doi: 10.1002/jor.21370

Figure 2. Chronic compression at 1X BW induces transient marrow changes that resolve within 8 weeks.

Figure 2

Representative longitudinal series of caudal vertebrae post-contrast CE-MRI in a 6X BW WT (A) and 1X BW WT (B) mice. Note that the BME in the 6X from 4 through 8 weeks (yellow arrows), while the BME in the 1X at 4 weeks (yellow arrow) resolved on its own at 6 and 8 weeks (blue arrow). Quantification of NMCE (C) illustrates the intensity changes associated with compression over time, means and standard errors (SE) are shown (n=5 tails; 10 vertebrae for each group) (*p<0.05 vs. wk 0; #p<0.05 vs. 1X at wk8). Representative AB/OG stained sections of 6X BW WT(D,E) and 1X BW WT (F,G) mice at 8 weeks taken at 5X magnification (D,F) and 20X magnification (E,G). Note the significant differences in both vascular sinus area (1X 13.4 ± 3.9% vs. 6X 35.0 ± 3.0%, p<0.01), and cellularity (1X 1886 ± 884 cell/mm2 vs. 6X 3265 ± 235 cell/mm2, p<0.01).