Table 1.
Characteristics of Men With Recurrence Following Radical Prostatectomy
| Characteristic | Salvage Treatment, No. (%)a |
P Value | |||
|---|---|---|---|---|---|
| None (n = 397) | Radiation Only (n = 160) | Radiation + Hormone (n = 78) | |||
| Age at surgery, mean (SD), y | 60.3 (5.80) | 58.3 (6.17) | 58.5 (6.27) | <.001 | |
| Race | |||||
| White, non-Hispanic | 345 (90.6) | 152 (95.0) | 66 (86.8) |  |
.19 |
| Black | 28 (7.4) | 7 (4.4) | 9 (11.8) | ||
| Other | 8 (2.1) | 1 (0.6) | 1 (1.3) | ||
| PSA level, median (range), ng/mL | |||||
| Preoperative | 9.6 (0.8–129.0) | 8.3 (0.1–57.1) | 7.7 (0.3–41.1) | .02 | |
| At start of radiation | NA | 0.70 (0.2–22.0) | 0.90 (0.3–30.0) | .03 | |
| Pathological Gleason score | |||||
| 4–6 | 63 (15.9) | 46 (28.8) | 11 (14.1) |  |
<.001 |
| 7 | 204 (51.4) | 89 (55.6) | 44 (56.4) | ||
| 8–10 | 130 (32.8) | 25 (15.6) | 23 (29.5) | ||
| Pathological stage | |||||
| Organ-confined | 42 (10.7) | 29 (18.2) | 6 (7.8) |  |
<.001 |
| Extraprostatic extension | 166 (42.1) | 104 (65.4) | 57 (74.0) | ||
| Seminal vesicle involvement | 69 (17.5) | 22 (13.8) | 11 (14.3) | ||
| Lymph node metastases | 117 (29.7) | 4 (2.5) | 3 (3.9) | ||
| Surgical margin status | |||||
| Negative | 225 (56.6) | 98 (61.3) | 42 (53.9) |  |
.48 |
| Positive | 172 (43.3) | 62 (38.8) | 36 (46.2) | ||
| PSA doubling time, median (range), mo | 12.0 (0.7–612.7) | 12.6 (0.9–563.4) | 7.0 (1.0–143.9) | .007 | |
| Period, y | |||||
| 1982–1988 | 90 (22.7) | 51 (31.9) | 17 (21.8) |  |
.09 |
| 1989–1991 | 52 (13.1) | 23 (14.4) | 7 (9.0) | ||
| 1992–2004 | 255 (64.2) | 86 (53.8) | 54 (69.2) | ||
| Time from surgery to recurrence, median (range), y | 3.0 (1.0–20.0) | 3.0 (1.0–18.0) | 2.5 (1.0–13.0) | .007 | |
| Developed metastases | 176 (45.3) | 43 (27.2) | 15 (19.5) | <.001b | |
| Death | |||||
| Prostate cancer | 89 (22.4) | 18 (11.3) | 9 (11.5) | .002b | |
| Any cause | 120 (31.1) | 30 (19.4) | 15 (19.7) | .007b | |
Abbreviations: NA, not applicable; PSA, prostate-specific antigen.
SI conversion factor: To convert PSA to μg/L, multiply by 1.0
a
Unless otherwise indicated.
b
P value is for a comparison among the crude proportions and does not reflect adjustment for survival time.