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let-7f alters expression of ADRB2 3′ UTR reporter genes. (A) Characteristics of the mutated ADRB2 3′UTR and let-7f constructs with mfe predictions. (B) Cotransfection of let-7f decreased pGL3-β2WT3′UTR in a dose-dependent fashion in HEK293 cells. *P = <0.05 vs. mock transfection, n = 4 experiments. (C) Mutation of the seed region of ADRB2 3′UTR, or of let-7, ablates effects on reporter expression. *P < 0.05 vs. mock transfection, n = 4 experiments.
