Table 1. General regulators of PKA-mediated protein phosphorylation are unaltered during aging.
Regulator | % of control | n |
---|---|---|
cAMP | 121 ± 20 | 6 |
PKA Cα | 126 ± 23 | 16 |
PP2A | 101 ± 15 | 15 |
PP1 inhibitor 1 | 82 ± 7 | 10 |
PP1 inhibitor 2 | 127 ± 16 | 14 |
Data represent relative levels (±SEM) in hippocampal extracts (except for PKA Cα, which shows relative amounts associated with immunoprecipitated CaV1.2) from 26-month-old rats as compared with those from 12-month-old rats, which equal 100%.