Fig. 4.
Structure elucidation of the stambomycins. Structures of stambomycins A–D proposed on the basis of HRMS and NMR spectroscopic analyses. Key COSY, HMBC, and NOESY correlations for structural elements that were not predicted by sequence analysis of the biosynthetic enzymes are indicated by bold lines, single-headed arrows, and double-headed arrows, respectively. 3J coupling constants observed in 1H NMR spectra for H-12/H-13 and H-49/H-50 are indicated.