Table 1.
Patient Characteristic | No. Patients |
---|---|
Age (y) | |
Median [range] | 41 [5–59] |
<20 | 8 |
20–29 | 4 |
30–39 | 16 |
40–59 | 33 |
Donor | |
Matched related | 42 |
Mismatched related | 8 |
Matched unrelated | 8 |
Mismatched unrelated | 3 |
Histologic Diagnosis (WHO classification) | |
Diffuse large B-cell | 7 |
Mantle Cell | 9 |
Lymphoblastic | 10 |
Anaplastic large cell | 7 |
Follicular | 10 |
Transformed | 11 |
Othera | 7 |
Stageb | |
II | 9 |
III | 11 |
IV | 26 |
Karnofsky Performance Status | |
≥ 80 | 50 |
< 80 | 11 |
Extranodal sites involved | |
≤ 1 | 51 |
> 1 | 10 |
LDH | |
Median [range] | 174 [104–474] |
≤ 210 | 39 |
> 210 | 22 |
Bone marrow involvementc | |
Yes | 14 |
No | 47 |
Prior chemotherapy regimens | |
Median [range] | 2 [1–8] |
1–2 | 32 |
>2 | 29 |
Response to last therapy | |
Complete remission | 15 |
Partial remission | 24 |
Stable disease | 10 |
Refractory | 12 |
Second-line age-adjusted IPI (sAAIPI) | |
Low-risk | 18 |
Low-intermediate risk (1) | 22 |
High-intermediate risk (2) | 13 |
High risk (3) | 8 |
Diffuse small cleaved cell (n=1), Diffuse mixed small and large cell (n=1), Small lymphocytic (n=1), HTLV-I associated Adult T cell (n=1), Angioimmunoblastic (n=1), Burkitt’s (n=1), Mycosis Fungoides (n=1);
Fifteen patients were in CR prior to allo-HSCT – highest stage since diagnosis: stage III=9, stage IV=52;
Bone marrow involvement at any time since diagnosis was present in 38 patients.