Table 1. Summary of cho mutants used.
Gene | Symbol | cho class | Ref. |
---|---|---|---|
atonal | ato | Specification | 21, 25, 37 |
beethoven | btv | Ciliary | 19, 25 |
touch-insensitive larva B | tilB | Axonemal | 20, 25 |
smetana | smet | Axonemal | 38 |
5D10 | 5D10 | Courtship defective | 19, 38 |
ato encodes a proneural bHLH protein that specifies cho precursor cells. In ato mutants, chos are absent in both adults and larvae. btv is a cho mutant that exhibits ultrastructural defects in the cho cilium, whereas smet and tilB mutants show male sterility in addition to deafness, suggesting specific defects of the axoneme. Finally, 5D10 mutants, found in a courtship defective auditory behavioral screen, show moderate cho dysfunction.