Table 3.
Physical Performance Measures and Pulmonary Function Tests for Ambulatory Participants with Multiple Sclerosis
| MS Total Group EDSS ≤6.5 (n=64) |
Mild Disability EDSS <4.0 (n=43) |
Moderate Disability EDSS 4.0–6.5 (n=21) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | Mean | SD | Mean | SD | 95% CI | Mean | SD | 95% CI | p* |
| Physical Performance | |||||||||
| 6MWT (m) | 337.2 | 160.7 | 402.4 | 136.7 | 361.5–449.1 | 193.7 | 108.5 | 153.3–255.8 | <0.001 |
| Male | 362.8 | 169.2 | 459.5 | 133.8 | 237.0 | 122.4 | |||
| Female | 322.2 | 156.4 | 380.1 | 156.0 | 175.0 | 99.2 | |||
| 6MWT Pred (m)** | 531.3 | 54.5 | 543.0 | 51.4 | 526.7–559.2 | 508.4 | 54.1 | 483.7–533.0 | |
| % of predicted distance walked*** | 62.8 | 27.8 | 74.3 | 23.2 | 67.0–81.6 | 40.2 | 21.8 | 30.3–50.1 | |
| Male | 66.6 | 27.1 | 81.6 | 19.4 | 47.2 | 23.8 | |||
| Female | 60.5 | 28.3 | 71.0 | 24.4 | 33.8 | 18.5 | |||
| FST (s) | 10.7 | 8.4 | 7.5 | 4.4 | 5.9–8.8 | 17.9 | 10.2 | 12.4–22.0 | <0.001 |
| FST power (kg-m/min) | 438.7 | 302.7 | 532.7 | 302.0 | 437.4–628.0 | 246.0 | 198.1 | 153.3–338.7 | <0.001 |
| Male | 544.3 | 376.5 | 715.5 | 376.0 | 321.7 | 246.1 | |||
| Female | 374.8 | 230.7 | 447.9 | 220.7 | 170.3 | 97.5 | |||
| SST (s) | 22.5 | 15.7 | 18.0 | 5.9 | 16.1–20.0 | 32.5 | 23.4 | 20.3–41.3 | <0.001 |
| BAL (s) | 15.7 | 10.5 | 18.9 | 9.9 | 9.3 | 8.4 | |||
| BAL (category) |
2.8 |
.2 |
2.4–3.1 |
2.0 |
.3 |
1.4–2.6 |
<0.001 |
||
| Pulmonary Function Measures | |||||||||
| FEV1 (l) | 2.73 | 0.69 | 2.83 | 0.63 | 2.66–3.06 | 2.56 | 0.78 | 2.15–3.86 | 0.142 |
| FEV1 Pred (%) | 97.27 | 18.69 | 99.60 | 15.10 | 95.5–104.5 | 93.43 | 24.77 | 79.1–101.5 | 0.226 |
| FVC (l) | 3.69 | 0.91 | 3.68 | 0.88 | 3.45–4.00 | 3.53 | 0.97 | 2.96–3.87 | 0.534 |
| FVC Pred (%) | 99.80 | 16.48 | 100.47 | 15.54 | 96.0–105.8 | 98.35 | 18.82 | 86.5–104.5 | 0.740 |
| FEV1/FVC | 0.77 | 0.01 | 0.78 | 0.08 | 0.75–0.80 | 0.74 | 0.13 | 0.69–0.81 | 0.122 |
| MIP (cm H2O) | 62.1 | 27.3 | 65.2 | 27.0 | 57.9–75.1 | 55.9 | 27.6 | 40.5–64.3 | 0.207 |
| MIP Pred (%) | 64.4 | 30.0 | 70.2 | 29.8 | 60.3–78.4 | 52.6 | 27.5 | 45.0–69.6 | 0.027 |
| MEP (cm H2O) | 79.1 | 37.2 | 84.5 | 37.9 | 73.6–98.1 | 67.9 | 33.7 | 50.7–71.4 | 0.095 |
| MEP Pred (%) | 49.3 | 20.8 | 52.9 | 19.3 | 45.2–59.8 | 41.9 | 21.9 | 28.1–50.3 | 0.047 |
| MVV (l/min) | 102.1 | 28.3 | 109.6 | 27.7 | 101.8–119.3 | 86.7 | 23.4 | 76.6–98.5 | 0.002 |
| MVV Pred (%) | 93.6 | 20.9 | 98.9 | 19.7 | 93.9–106.3 | 82.6 | 19.1 | 76–6-95.2 | 0.003 |
One-way ANOVA significant at p<0.05
Predicted 6MWT distance=493+(2.2×height [cm])−(0.93×weight [kg]) – (5.3×age). For men add 17 m. Subtract 100 m for lower limit of normal range.20
Percentage of predicted distance walked=(actual 6MWT÷predicted 6MWT)×100%.
MS=multiple sclerosis; EDSS=Expanded Disability Status Scale; 6MWT=6-Minute Walk Test distance; FST=Functional Stair Test; SST=Sit-to-Stand Test; BAL=single or tandem static standing balance; FEV1=forced expiratory volume in 1 second; FVC=forced vital capacity; FEV1/FVC=forced expiratory volume in 1 second / forced vital capacity; MIP=maximal inspiratory pressure; MEP=maximal expiratory pressure; MVV=maximal voluntary ventilation