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. 2003 Dec 10;100(26):16065–16070. doi: 10.1073/pnas.2535311100

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Fig. 3. — Contribution of TRPC4 proteins to 5-HT-mediated GABA release from F2 terminals. (A and D) Changes in membrane current variance on bath-application of 5-HT (100 μM, 1.5 min) and acetyl-β-methylcholine (MCh) (250 μM, 1.5 min) in relay cells of wild-type (TRPC4^+/+, A) and TRPC4 knockout (TRPC4^-/-, D) mice. (B) Changes in membrane current variance on bath-application of mGluR agonists DHPG (100 μM) and (S)-3-carboxy-4-hydroxyphenylglycine (S3-C4HPG) (250 μM) in TRPC4^+/+ mice. (C) Occlusion of αM-5-HT (100 μM) induced an increase in IPSC activity during the nearly maximal action of DHPG (100 μM) in TRPC4^+/+ mice. (E) Persistence of DHPG-induced increase in IPSC activity in TRPC4^-/- mice. (F) Summary of the effects of 5-HT, MCh, and DHPG, normalized to basal membrane current variance before application of substances, for wild-type (TRPC4^+/+) and TRPC4-deficient (TRPC4^-/-) mice, respectively. All recordings were obtained in the presence of TTX (1 μM). Error bars show SEM.