Table 4.

Subantimicrobial dose doxycycline (SDD) effects on serum lipid levels over the two-year clinical trial

Cholesterol Measure		Placebo Group (n =62)			SDD Group (n =51)			p-value*
		Median	Mean	SD	Median	Mean	SD
Total Cholesterol (mg/dl)								0.6
Baseline		216.50	229.10	53.50	225.00	230.80	60.52
One Year		218.00	224.90	47.15	216.00	225.50	50.67
Two Year		218.00	216.70	46.44	223.00	229.10	46.97
HDL Cholesterol (mg/dl)								0.3
Baseline		58.00	64.77	27.01	55.00	57.69	19.83
One Year		57.00	63.82	24.31	57.00	60.92	17.81
Two Year		60.00	64.07	23.44	64.00	61.90	18.31
LDL Cholesterol (mg/dl)								0.4
Baseline		128.50	134.70	42.42	125.40	136.00	49.89
One Year		120.80	128.80	39.27	126.40	130.50	38.42
Two Year		128.80	123.69	37.78	126.40	132.40	41.93
VLDL Cholesterol (mg/dl)								0.2
Baseline		25.20	29.66	15.10	27.60	37.13	26.52
One Year		28.80	32.27	17.84	29.20	34.13	24.20
Two Year		24.00	28.97	17.67	29.40	34.77	27.18
Triglyceride (mg/dl)								0.2
Baseline		126.00	149.00	74.87	138.00	185.70	132.60
One Year		144.00	161.30	89.22	146.00	170.60	121.00
Two Year		120.00	144.80	88.37	147.00	173.80	135.90

^*p-values correspond to the comparison of aggregated 1-year and 2-year mean (Total, HDL, and LDL Cholesterol) or median (VLDL Cholesterol and Triglyceride) biomarker measures between SDD and placebo subjects.

SD=standard deviation

HDL = high-density lipoprotein

LDL = low-density lipoprotein

VLDL = very low-density lipoprotein