Table 5.

Subantimicrobial dose doxycycline (SDD) effects on serum lipid levels in women more than 5 years postmenopausal over the two-year clinical trial

Cholesterol Measure		Placebo Group (n = 40)			SDD Group (n = 31)			p-value*
		Median	Mean	SD	Median	Mean	SD
Total Cholesterol (mg/dl)								0.4
Baseline		211.50	227.45	51.45	211.00	226.48	70.20
One Year		217.00	221.15	47.87	213.00	226.61	59.97
Two Year		212.00	216.83	52.49	220.00	229.13	54.94
HDL Cholesterol (mg/dl)								0.01
Baseline		56.50	61.00	25.77	51.00	52.26	17.79
One Year		52.00	58.28	22.93	54.00	59.16	18.31
Two Year		54.50	60.65	24.22	62.00	59.94	19.27
LDL Cholesterol (mg/dl)								0.4
Baseline		128.80	132.98	39.33	122.00	130.60	58.30
One Year		121.00	126.99	38.44	117.60	129.30	44.28
Two Year		127.00	123.95	41.06	121.20	129.32	49.18
VLDL Cholesterol (mg/dl)								0.06
Baseline		32.90	33.48	15.09	35.00	43.63	31.19
One Year		36.60	35.88	16.11	30.40	38.15	28.79
Two Year		28.40	32.23	15.12	31.80	39.88	32.84
Triglyceride (mg/dl)								0.06
Baseline		164.50	168.38	74.18	175.00	218.13	155.96
One Year		183.00	179.41	80.56	152.00	190.74	143.94
Two Year		142.00	161.13	75.58	159.00	199.39	164.18

^*p-values correspond to the comparison of aggregated 1-year and 2-year mean (Total, HDL, and LDL Cholesterol) or median (VLDL Cholesterol and Triglyceride) biomarker measures between SDD and placebo subjects.

SD=standard deviation

HDL = high-density lipoprotein

LDL = low-density lipoprotein

VLDL = very low-density lipoprotein