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. Author manuscript; available in PMC: 2011 Sep 1.
Published in final edited form as: J Immunol. 2010 Jul 28;185(5):3076–3085. doi: 10.4049/jimmunol.0904214

FIGURE 1.

FIGURE 1

Differential effects of iNOS gene deletion during airway inflammation in response to acute or chronic exposure to OVA in mice. C57BL/6J WT or C57BL/6J iNOS−/− mice were subjected to the acute or the chronic challenge protocol or left untreated; mice were sacrificed 48 h after the last challenge. Lungs were either subjected to BAL (A and B) or formalin fixation (C). A and B, Cells of BAL fluids were differentially stained, and total, Eos, MQ, and Neut were counted. Data are expressed as total number of cells per mouse. Data are means ± SD of values from at least six mice per group. C, H&E stain of lung sections from the different experimental groups; scale bars, 4 μm. Original magnification ×20. Arrows indicate sites of inflammation. *Difference from unchallenged mice, p < 0.01; #difference from WT mice challenged with OVA, p < 0.01. Eos, eosinophils; MQ, macrophages; Neut, neutrophils.