Table 1.
Hypogonadal Subjects and Studies Performed
| Subject Number |
Age (years) |
Diagnosis | Free Testosterone (pg/ml)* |
Studies Performed | ||
|---|---|---|---|---|---|---|
| TRECs | Naive T Cells |
Testosterone Replacement |
||||
| 1 | 56 | Primary hypogonadism |
44.9 | ✓ | ||
| 2 | 53 | Hypogonadotrophic hypogonadism |
43.1 | ✓ | ||
| 3 | 56 | Hypogonadotrophic hypogonadism |
21.0 | ✓ | ||
| 4 | 33 | Hyogonadism due to hyperprolactinemia |
17.4 | ✓ | ||
| 5 | 42 | Primary hypogonadism |
43.0 | ✓ | ✓ | ✓ |
| 6 | 64 | Primary hypogonadism |
45.5 | ✓ | ✓ | |
*
(normal range 47.0–244.0 pg/ml)
TRECs: T cell receptor excision circles quantitated by RT=PCR
Naïve T cells: CD45RA+ cells quantitated by flow cytometry
Testosterone Replacement: studies repeated after androgen repletion