A. GEO tumors at 2, 8 and 24 hours after 12 days of rapamycin (20mg/kg) or vehicle treatment and effects on mTOR signaling were measured. Downstream effector phosphorylation of 4E-BP1 37/46 (light gray bars), Akt 473 (black bars), and S6 235/236 (dark gray bars) are shown (n=2). B. Mice bearing GEO xenografts were treated for 12 days with OSI-027 (65mg/kg) or vehicle and tumors collected at 2, 8, and 24 hours. Phosphorylation of mTOR signaling is shown (n=2). C–D. Mice bearing GEO xenograft tumors were treated with OSI-027 or rapamycin (C) or OXA-01 or rapamycin (D) and tumor volumes were plotted against time.