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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Cancer Res. 2011 Mar 1;71(5):1573–1583. doi: 10.1158/0008-5472.CAN-10-3126

Figure 2. Effects of OSI-027, OXA-01, and rapamycin on tumor growth and pharmacodynamics.

Figure 2

A. GEO tumors at 2, 8 and 24 hours after 12 days of rapamycin (20mg/kg) or vehicle treatment and effects on mTOR signaling were measured. Downstream effector phosphorylation of 4E-BP1 37/46 (light gray bars), Akt 473 (black bars), and S6 235/236 (dark gray bars) are shown (n=2). B. Mice bearing GEO xenografts were treated for 12 days with OSI-027 (65mg/kg) or vehicle and tumors collected at 2, 8, and 24 hours. Phosphorylation of mTOR signaling is shown (n=2). C–D. Mice bearing GEO xenograft tumors were treated with OSI-027 or rapamycin (C) or OXA-01 or rapamycin (D) and tumor volumes were plotted against time.