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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Cancer Res. 2011 Mar 1;71(5):1573–1583. doi: 10.1158/0008-5472.CAN-10-3126

Figure 5. Effects of mTOR inhibition on tumor vessels.

Figure 5

A. RIP-Tag2 tumor blood vessels (CD31; green) after treatment for 7 days. B. Time course quantifications of OXA-01 treatment on CD31 area density (left) and the comparison of 7-day treatment with vehicle, OXA-01, rapamycin (Rapa), and OSI-930 (right). C. Confocal images of RIP-Tag2 tumor blood vessels (CD31; green) and basement membrane (type IV collagen; red) after treatment for 7 days. D. Confocal images and quantification of tumor vessel sprouts after treatment for 7 days. Scale bar in D represents 100 μm in A; 50 μm in C; 12 μm in D. *P< 0.05 vs. vehicle. †P<0.05 vs. OXA-01. ‡P<0.05 vs. rapamycin.