Table 2.

Clinical course of EAE in WT and PD-L1^−/− mice^a

Mice	Incidence	Onset	Peak	CDI	Mortality
WT Ctrl	7/7	12.8± 1.5	4.6± 0.3⋆	35.9± 3.9⋆	0
WT E2	0/7	0± 0	0± 0	0± 0	0
PD-L1−/− Ctrl	8/8	11± 1.5	4.8± 0.3*	37.1± 2.5*	0
PD-L1−/− E2	6/7	15± 1.3	4.5± 0.5⋆	30.1± 3.5⋆	0

^a)Statistical evaluation of EAE disease course, including the Cumulative Disease Index (CDI), through Day 24 post-immunization.

^*p≤0.05, compared to the WT E2-implanted mice(One-way ANOVA with Bonferroni post hoc test). Additional information for the experiment shown in Fig. 5.

^*p≤0.05 as compared to the WT E2 group.