Table 4.

Effect of weight loss on metabolic parameters and brachial artery characteristics

	Modest weight loss n = 27		Significant weight loss n = 40
	Baseline	1 year	Baseline	1 year
BMI, kg/m2	45 ± 9	43 ± 9a	48 ± 9	34 ± 7a
Weight, kg	127 ± 29	122 ± 29a	131 ± 24	94 ± 17a
Systolic blood pressure, mmHg	132 ± 18	127 ± 18	131 ± 14	130 ± 14
Diastolic blood pressure, mmHg	74 ± 13	74 ± 12	72 ± 11	74 ± 11
Total cholesterol, mg/dl	182 ± 28	181 ± 28	192 ± 34	182 ± 33
HDL cholesterol, mg/dl	46 ± 11	48 ± 11	52 ± 19	53 ± 14
LDL cholesterol, mg/dl	102 ± 30	107 ± 28	108 ± 28	106 ± 27
Triglycerides, mg/dl	158 ± 124	136 ± 86	161 ± 100	120 ± 70b
Glucose, mg/dl	104 ± 36	104 ± 29	114 ± 43	99 ± 45b
Insulin, μIU/ml	13.4 ± 10.1	13.5 ± 10.0	20.3 ± 16.9	7.5 ± 6.1a
hsCRP, mg/l	13.6 ± 5.2	11.5 ± 5.2b	10.3 ± 6.6	5.0 ± 5.5a
Baseline diameter, mm	4.11 ± 0.86	4.19 ± 0.79	4.21 ± 0.71	4.02 ± 0.66c
Post-nitroglycerin diameter, mm	4.76 ± 0.86	4.84 ± 0.92	5.14 ± 0.62	4.78 ± 0.60d
Baseline flow velocity, cm/sec	19 ± 8	22 ± 9	21 ± 7	23 ± 12
Baseline flow, ml/min	166 ± 116	190 ± 117	174 ± 65	167 ± 81
Baseline shear stress, dyne/cm2	13.5 ± 6.7	14.9 ± 6.2	14.4 ± 6.0	16.7 ± 11.1e

Mean ± SD.

^ap < 0.001,

^bp < 0.05,

^cp = 0.01,

^dp < 0.01,

^ep = 0.08 compared to baseline. hsCRP; high-sensitivity C-reactive protein.