Table 1.

Characteristics of 49,653 initiators of selective COX-2 inhibitors or nonselective NSAIDs as defined during 6 months prior to first medication use.

	Initiators of Cox-2 selective NSAIDs (n=32,042)	Initiators of nonselective NSAIDs (n=17,611)
	No.(%)	No.(%)	OR(95% CI)
Age 75 years or older	24,079(75)	11,496(65)	1.61(1.55–1.67)
Female sex	27,528(86)	14,293(81)	1.42(1.35–1.49)
Race: white	30,583(95)	15,808(90)	2.39(2.23–2.57)
black	1,133(4)	1,580(9)	0.37(0.34–0.40)
other	326(1)	223(1)	0.80(0.68–0.95)
Charlson comorbidity score >= 1	24,343(76)	12,521(71)	1.29(1.23–1.34)
Use of >4 distinct drugs in prior year	24,120(75)	11,852(67)	1.48(1.42–1.54)
>4 physician visits in prior year	22,919(72)	11,363(65)	1.38(1.33–1.44)
Hospitalized in prior year	9,804(31)	4,591(26)	1.25(1.20–1.30)
Nursing home resident	2,671(8)	996(6)	1.52(1.41–1.64)
Prior use of gastroprotective drugs	8,785(27)	3,600(20)	1.47(1.41–1.54)
Prior use of warfarin	4,252(13)	1,153(7)	2.18(2.04–2.34)
Prior use of oral steroids	2,800(9)	1,373(8)	1.13(1.06–1.21)
History of OA	15,549(49)	5,898(33)	1.87(1.80–1.95)
History of RA	1,602(5)	476(3)	1.90(1.71–2.10)
History of peptic ulcer disease	1,189(4)	426(2)	1.55(1.39–1.74)
History of gastrointestinal hemorrhage	551(2)	196(1)	1.55(1.32–1.83)
History of hypertension	23,332(76)	12,363(70)	1.14(1.09–1.18)
History of congestive heart failure	9,727(30)	4,328(25)	1.34(1.28–1.40)
History of coronary artery disease	5,266(16)	2,603(15)	1.13(1.08–1.19)