Table 4.

Significant SNPs (P < 0.05) in telomere biology genes associated with telomere length before correction for multiple tests

Gene	SNP	Genomic position		Minor allele	Beta†	SE	P	Padj
ATM	rs1800056	Chr11: 107643213	Ex17-67 (F858L)	C	0.478	0.164	0.0041	0.122
BLM	rs7183841	Chr15: 89095901	IVS3-120	C	0.106	0.050	0.0351	1.000
BLM	rs4932363	Chr15: 89124105	IVS12-2951	A	0.177	0.086	0.0416	1.000
MEN1	rs670358	Chr11: 64348255	downstream	A	0.140	0.052	0.0083	0.066
MYC	rs4645946	Chr8: 128817567	Ex1+70	A	0.432	0.168	0.0110	0.274
NOLA1	rs10516559	Chr4: 110966179	downstream	C	0.138	0.066	0.0394	0.433
NOLA2	rs6601217	Chr5: 177501445	upstream (in RMND5B)	G	-0.114	0.043	0.0094	0.057
NOLA2	rs6873523	Chr5: 177505533	upstream (in RMND5B)	C	-0.108	0.042	0.0118	0.071
NOLA2	rs13189047	Chr5: 177511481	IVS2-881	A	-0.089	0.044	0.0422	0.253
NOLA3	rs2169480	Chr15: 32422661	downstream	G	-0.093	0.043	0.0304	0.455
POT1	rs4360236	Chr7: 124313975	IVS2+5581	T	0.124	0.054	0.0244	0.170
POT1	rs727505	Chr7: 124249317	upstream	A	-0.091	0.043	0.0373	0.261
RAD50	rs6884762	Chr5: 131966629	IVS13-262	T	0.286	0.115	0.0140	0.238
RAD51L3	rs9915078	Chr17: 30467328	IVS3+2305	G	0.173	0.065	0.0080	0.144
TEP1	rs2678685	Chr14: 19949151	IVS1+2253	G	0.103	0.037	0.0061	0.250
TEP1	rs4246977	Chr14: 19952431	downstream	C	-0.080	0.037	0.0316	1.000
TERC	rs9860874	Chr3: 170968965	downstream (in ARPM1)	A	-0.114	0.046	0.0145	0.087
TERC	rs12638862	Chr3: 170960200	upstream	G	-0.114	0.046	0.0152	0.091
TERC	rs12696304	Chr3: 170963965	upstream	G	-0.105	0.049	0.0343	0.206
WRN	rs11574212	Chr8: 31046197	IVS7+812	T	0.223	0.107	0.0385	1.000

^†Represents the effect of each minor allele on telomere length from a linear regression model adjusting for age and gender; SE = standard error; P_adj = Bonferroni corrected P by gene.