Table 4.

Genotype distributions and estimated risk of the ancestral allele of the polymorphisms in CTNNBL1 in the hospital-based Czech sample population: unadjusted and age adjusted results

SNP	Allelea	Sample	Genotype distribution		Codominat Model						Dominant Model
			DD-DA-AA		DD vs DA			DD vs AA			DD vs DA+AA
			Cases	Controls	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P
rs6067377	T/C	all samples	252-368-127	266-360-115	1.08	0.86-1.35	0.51	1.17	0.86-1.58	0.33	1.10	0.89-1.36	0.38
		adjusted for age	240-359-125	266-360-115	1.11	0.87-1.41	0.42	1.12	0.81-1.54	0.50	1.11	0.88-1.39	0.39
rs2344481	A/G	all samples	628-112-2	658-80-3	1.47	1.08-1.99	0.01	0.70	0.12-4.19	0.69	1.44	1.06-1.95	0.02
		adjusted for age	606-111-2	658-80-3	1.40	1.01-1.94	0.04	0.77	0.12-5.09	0.79	1.38	1.00-1.91	0.05
rs238302	A/G	all samples	82-335-327	85-330-324	1.05	0.75-1.48	0.77	1.05	0.75-1.47	0.79	1.05	0.76-1.45	0.77
		adjusted for age	82-335-327	85-330-324	1.12	0.78-1.61	0.54	1.09	0.76-1.57	0.63	1.11	0.79-1.56	0.56
rs2281148	C/T	all samples	45-242-457	27-237-478	0.61	0.37-1.02	0.06	0.57	0.35-0.94	0.03	0.59	0.36-0.96	0.03
		adjusted for age	42-234-445	27-237-478	0.64	0.37-1.10	0.11	0.62	0.37-1.05	0.08	0.63	0.37-1.05	0.08
rs2235460	A/G	all samples	100-349-270	124-368-243	1.18	0.87-1.59	0.29	1.38	1.01-1.89	0.05	1.26	0.94-1.67	0.12
		adjusted for age	96-342-262	124-368-243	1.16	0.83-1.61	0.38	1.29	0.92-1.82	0.14	1.21	0.89-1.66	0.22
rs6067889	A/G	all samples	448-262-32	448-255-30	1.03	0.83-1.28	0.81	1.07	0.64-1.79	0.81	1.03	0.84-1.27	0.77
		adjusted for age	432-257-30	448-255-30	1.07	0.85-1.36	0.55	1.10	0.63-1.92	0.75	1.08	0.86-1.35	0.52
rs4811233	C/G	all samples	358-295-80	378-265-81	1.18	0.94-1.47	0.15	1.04	0.74-1.47	0.81	1.14	0.93-1.41	0.20
		adjusted for age	343-289-78	378-265-81	1.20	0.96-1.50	0.10	1.06	0.75-1.50	0.74	1.17	0.95-1.44	0.14
rs6067923	G/Ab	all samples	339-322-84	356-291-81	1.16	0.94-1.44	0.18	1.09	0.78-1.53	0.62	1.15	0.93-1.41	0.19
		adjusted for age	330-331-79	356-291-81	1.23	0.99-1.53	0.07	1.05	0.75-1.48	0.77	1.19	0.97-1.46	0.10

OR odds ratio; CI confidence interval; A ancestral allele, D derived allele.

^aSecond allele represents the ancestral allele for each locus.

^bancestral allele unknown, the major allele was used as reference.

Total numbers of cases and controls may slightly vary among SNPs due to missing genotypes. Bold numbers indicate statistical significance at 5% level. The results were adjusted for age due to significant difference in the median age distribution among the case and the control group.