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. 2011 Jan 19;36(5):960–969. doi: 10.1038/npp.2010.234

Figure 5.

Figure 5

In the NIH paradigm, ATR-deleted mice exhibit altered antidepressant response. (a) In a novel environment, AAV.Cre-injected mice exhibited a reduction in latency to consume peanut butter chips compared with AAV.eGFP-injected mice (#p<0.0001, n=7–8 per group). There was a significant effect of chronic DMI treatment (12.5 mg/kg b.i.d., 24 days) only in the AAV.eGFP-injected mice (*p<0.05). (b) CDP administered 30 min before novel testing reduced latency to feed in both control and ATR-deleted mice (##p<0.0001 vs saline-treated, n=8–10 per group). (c) DMI significantly reduced immobility in the FST in both control and ATR-deleted mice (##p<0.0001 vs saline-treated, n=8–10 per group). DMI was administered 24 h (10 mg/kg), 5 h (10 mg/kg), and 1 h(20 mg/kg) before the 6-min swim test. Immobility was measured over the final 4 min. (d) ATR deletion reduced cell proliferation in the dentate gyrus (###p<0.001 vs AAV.eGFP-treated, n=7–8 per group). Chronic DMI (12.5 mg/kg b.i.d., 24 days) had no effect on cell proliferation. Error bars indicate SEM.