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. 2011 Feb 2;36(5):979–992. doi: 10.1038/npp.2010.236

Figure 2.

Figure 2

SNI inhibits LTP in CA3–CA1 synapses in a time-dependent manner. (a) SNI did not affect the baseline of fEPSPs and LTP induction by HFS (100 Hz, 50 pulses, four trains with 15 s intervals), which was delivered at 1 h after nerve injury (n=5 in each group). Insert: the raw traces of fEPSPs before (top trace) and after (bottom trace) HFS. (b and c) The time courses of potentiation by HFS in 18–20 h and 6–10 day SNI group (n=6 in each group). (d and e) The recordings were made following behavioral test as illustrated in Figure 1a–c and Figure 1g–i (n=10–15 in each group). (f) The recordings were made in rats (n=5 in SNI group and n=20 in sham group) that did not exhibit allodynia but had working memory deficits, as shown in Figure 1d–f. Data are presented as means±SEM.