Table 4.

Associations between TLR2 markers and leprosy, leprosy type, and reversal reaction (RR) in all ethnic groups.

Marker	Leprosy status				Leprosy type				RR
	Leprosy (n = 441)	Control (n = 197)	OR	P	Lepromatous (n = 298)	Tuberculoid (n = 138)	OR	P	RR (n = 66)	No RR (n = 150)	OR	P
SNP
597C→T
0/0	38.3	34.7	1.00		39.4	35.9	1.00		48.3	27.3	1.00
0/1	45.9	51.1	0.78	.24	45.4	46.9	0.91	.69	38.3	56.1	0.31	.003
1/1	15.8	14.2	0.99	.97	15.1	17.2	0.82	.56	13.3	16.5	0.39	.07
1350T→C
0/0	89.4	89.1	1.00		88.7	90.9	1.00		94.7	89.0	1.00
0/1	10.3	10.9	1.15	.66	10.9	9.1	1.33	.44	5.3	11.0	0.38	.15
1/1	0.2	0.0			0.4	0.0			0.0	0.0
Microsatellitea allelic length
280 bp
0/0	43.0	43.3	1.00		43.0	43.8	1.00		30.5	49.6	1.00
0/1	43.2	46.0	0.91	.64	43.3	43.1	1.11	.67	47.5	44.7	1.58	.22
1/1	13.8	10.7	1.41	.28	13.7	13.1	1.08	.83	22.0	5.7	7.09	.001
282 bp
0/0	75.9	72.2	1.00		72.9	81.5	1.00		79.7	72.3	1.00
0/1	22.7	25.7	0.86	.51	26.1	16.2	1.82	.04	18.6	26.2	0.53	.13
1/1	1.4	2.1	0.76	.71	1.1	2.3	0.49	.39	1.7	1.4	0.96	.97
284 bp
0/0	73.0	77.5	1.00		73.6	72.3	1.00		74.6	73.8	1.00
0/1	24.6	19.8	1.15	.56	24.3	24.6	0.87	.58	23.7	24.1	1.02	.97
1/1	2.4	2.7	1.13	.84	2.1	3.1	1.08	.91	1.7	2.1	1.18	.90
288 bp
0/0	86.2	90.9	1.00		89.1	80.0	1.00		86.4	86.5	1.00
0/1	13.6	9.1	1.32	.37	10.6	20.0	0.47	.01	13.6	13.5	1.20	.71
1/1	0.2	0.0			0.4	0.0			0.0	0.0
290 bp
0/0	82.8	74.9	1.00		83.8	80.8	1.00		79.7	83.0	1.00
0/1	16.2	23.5	0.63	.05	15.1	18.5	0.85	.57	20.3	15.6	1.27	.58
1/1	1.0	1.6	0.31	.18	1.1	0.8	2.24	.50	0.0	1.4

NOTE. Listed frequencies (%) are for the presence of 0 (0/0), 1 (0/1), or 2 (1/1) copies of the genotype or allelic length. P values were calculated using a logistic regression model including 0/1 and 1/1, with 0/0 as the reference (a general model that did not assume any particular type of inheritance was used), adjusted for age group, sex, and ethnicity. OR, odds ratio.

^aMicrosatellite indicates the size of the polymerase chain reaction (PCR) product.