Table 6.

Associations between TLR2 markers and leprosy type in the different ethnic groups.

Marker	All		Oromo		Amhara		Gurage
	Lepromatous (n = 298)	Tuberculoid (n = 138)	Lepromatous (n = 137)	Tuberculoid (n = 53)	Lepromatous (n = 89)	Tuberculoid (n = 36)	Lepromatous (n = 67)	Tuberculoid (n = 45)
282-bp microsatellitea allelic length
0/0	72.9	81.5	79.1	83.3	66.7	77.8	68.2	81.4
0/1	26.1	16.2	19.4	16.7	32.1	13.9	31.8	18.6
1/1	1.1	2.3	1.6	0.0	1.2	8.3	0.0	0.0
0/1 + 1/1	27.1	18.5	20.9	16.7	33.3	22.2
Dominant modelb
OR (95% CI)	1.64 (0.96–2.81)		1.22 (0.50–2.99)		1.53 (0.59–3.94)		2.02 (0.75–5.44)
P	.07		.66		.38		.16
288-bp microsatellitea allelic length
0/0	89.1	80.0	86.8	75.0	91.7	83.3	89.4	81.4
0/1	10.6	20.0	13.2	25.0	7.1	16.7	10.6	18.6
1/1	0.4	0.0	0.0	0.0	1.2	0.0	0.0	0.0
0/1 + 1/1	10.9	20.0			8.3	16.7
Dominant modelb
OR (95% CI)	0.49 (0.27–0.90)		0.59 (0.24–1.46)		0.41 (0.11–1.45)		0.49 (0.16–1.51)
P	.02		.25		.16		.22
Haplotype 288-T-T
0/0	90.2	81.3	88.8	78.4	92.1	83.3	89.6	81.8
0/1	9.5	18.7	11.2	21.6	6.7	16.7	10.4	18.2
1/1	0.3	0.0	0.0	0.0	1.1	0.0	0.0	0.0
0/1 + 1/1	9.8	18.7			7.9	16.7
Dominant modelb
OR (95% CI)	0.49 (0.26–0.90)		0.60 (0.23–1.54)		0.39 (0.11–1.40)		0.50 (0.16–1.55)
P	.02		.28		.15		.23

NOTE. Listed frequencies (%) are for the presence of 0 (0/0), 1 (0/1), or 2 (1/1) copies of the marker. Allele carriage frequencies (0/1 + 1/1) are presented for convenience. Odd ratios {OR} and P values were computed under the best-fitting model, which was determined by the likelihood ratio test. The results are adjusted for age group and sex. For the analysis comprising all ethnic groups, results are also adjusted for ethnicity. Haplotype nomenclature refers to 3 loci composed of microsatellite 288,597T and 1350T. CI, confidence interval.

^aMicrosatellite indicates the size of the polymerase chain reaction (PCR) product.

^b(0/1 + 1/1) vs. 0/0.