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. 2011 Mar 31;8:27. doi: 10.1186/1742-2094-8-27

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Copyright ©2011 Lyons et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Age-related NK cell infiltration into the brain. A, CD161⁺NKp30⁺cells was increased in the hippocampus of aged compared with young rats (*p < 0.05; student's t-test for independent means; n = 6). The panel to the right in Figure 2b shows a sample flow cytometry plot, demonstrating increased expression of NKp30 in the aged brain, after gating on the CD161⁺cells. B, IL-2 increased IFNγ release from CD161⁺cells obtained from rat hippocampus and C, cortex, and D, from a human NK cell line (*p < 0.05; ***p < 0.001; student's t-test for independent means; n = 6). E, IL-2 concentration was not significantly altered in hippocampus of aged and young rats.