Table 1. List of genes suppressed or rescued by exosomes isolated from M.tb infected cells following stimulation with IFN-γ.
| IFN- γ inducible genes suppressed by Rvexosomes | Genes rescued by Rvexosomes from IFN- γ mediated suppression | ||
| Ten most regulated genes | |||
| Gene | Fold change | Gene | Fold change |
| Cnn3, calponin 3, acidic | −21.67* | Edg1,endothelial differentiation | 15.06* |
| Bcl2l14, Bcl-2 like14 | −17.09* | sphingolipid G-protein coupled receptor1 | |
| (apoptosis facilitator) | Ccl9 | 11.75* | |
| Mpa2l,macrophage activation 2 like | −14.49* | Clec4d, C-type lectin domain4 | 11.03* |
| Cxcl10,(chemokine C-X-C motif) | −13.15* | Lhfpl2,lipoma HMGIC | 10.7* |
| Ligand 10 | fusion partner like 2 | ||
| Cd274 | −9.54* | Igf1, insulin like growth factor1 | 10.28* |
| Slamf8,SLAM family member8 | −7.39* | Fabp4,fatty acid binding protein4 | 10.14* |
| Gbp5,guanylate nucleotide binding protein5 | −7.04* | Igfbp4,insulin like growth factor binding protein4 | 9.75* |
| Lrrc8c, Leucine rich repeat containing 8 family member C | −6.96* | cbr2, carbonyl reductase2 | 7.78* |
| TimD4,T-cell immunoglobulin | −6.82* | Emp1,epithelial membrane protein1 | 7.28* |
| Cd40 | −6.70* | Xylt2, xylosyltransferase2 | 6.68* |
*Genes common to both treatment with Rv exosomes/H37Rv infection.