. 2011 Apr 14;7(4):e1002042. doi: 10.1371/journal.pgen.1002042

Table 1. Incidence and age-of-onset of malignant sarcomas in MD mouse models.

Genotype	Strain background	Cohort	Sarcomas	Incidence^a	Mean age	[CI (95%)]	Female/male ratio	Tumor site predilection
Dystrophin
Dmd ^−/− (mdx)	C57BL/10	n = 122	48	39%	539 d	[516–562]	1: 1.1	proximal hind limb, trunk, head & neck
	C57BL/10× B6C3Fe^b	n = 46	8	17%	580 d	[460–700]	1.7: 1	proximal hind limb, trunk, head & neck
	C57BL/6× BALB/c^c	n = 99	10	10%	651 d	[567–735]	1: 1.4	proximal hind limb, fore limb, head & neck
	BALB/c	n = 82	7	9%	515 d	[413–607]	1: 1.3	proximal hind limb, head & neck
	C3H	n = 60	9	15%	523 d	[411–635]	2.5: 1	proximal hind limb, trunk, head & neck
Dmd ^−/−(mdx-3Cv)	C57BL/6× B6C3Fe^d	n = 55	3	5%	663 d	n.a.	n.a.	n.a.
Dysferlin
Dysf ^−/−	C57BL/10	n = 151	35	23%	640 d	[601–679]	1: 2.9	proximal hind limb and trunk
	C57BL/10× B6C3Fe^b	n = 78	17	22%	755 d	[686–804]	1: 2.9	trunk
Large
Large ^−/− (myd)	B6C3Fe^c	n = 71	1	1%	278 d	n.a.	n.a.	n.a.
Calpain
Capn3 ^−/−	C57BL/6× [129/Sv: C57BL/6]^d	n = 19	1	5%	716 d	n.a.	n.a.	n.a.
Dystrophin-Dysferlin
Dmd ^−/− Dysf ^−/−	C57BL/10	n = 89	42	47%	389 d	[369–409]	1: 2.4	proximal hind limb, fore limb, trunk, head & neck
Dystrophin-Calpain
Dmd ^−/− Capn3 ^−/−	C57BL/10× [129/Sv: C57BL/6]^b	n = 55	24	44%	391 d	[360–422]	1: 1.6	proximal hind limb, trunk

a Incidences of clinically overt sarcomas. Different C57BL/6 proportions in mixed backgrounds are indicated: b 25%, c 50%, and d 75% C57BL/6.

n.a.: not applicable.