Figure 5. LGP2 positively regulates MVA-induced IFN and cytokine induction in MEFs.

MEFs from wild-type mice (+/+) and LGP2-deficient mice (−/−) were infected with MVA at a multiplicity of infection of 10 for the indicated amount of time and total RNA was isolated. Relative abundance of IFNβ, CXCL10 and CCL5 mRNA was determined by quantitative RT-PCR. A representative experiment of three independent experiments is shown. Student's t test was performed: *(p<0.05), **(p<0.01), and ***(p<0.005).