Fig. 5.

Blockade of gp120-induced enhancement of outward K⁺ currents by H89, a specific inhibitor for PKA. A. Representative current traces recorded from a control cell (Ctrl) and cells treated respectively with H89 alone, gp120 alone and gp120+H89. The voltage protocol used to generate outward K⁺ current was the same as the one shown in Fig. 1. B. I–V relationship illustrating the outward K⁺ current densities as a function of voltage from the current traces shown in A. C. Summarized bar graphs showing average outward K⁺ current densities measured at a voltage step +60mV from microglia treated with H89 alone, gp120 alone and gp120+H89. Note a significant blockade of gp120 enhancement of outward K⁺ currents recorded in microglia. * p<0.05 vs. ctrl, # p<0.05 vs. gp120.