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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Glia. 2011 Mar 28;59(6):946–958. doi: 10.1002/glia.21167

Fig. 4.

Fig. 4

Elevation of ISG15 protein in the spinal cord of ALS patients. ISG15 protein levels in lysate samples were increased in ALS patients compared to controls (top panel) (A). Bottom panel shows densitometry quantitation of ISG15 in all ALS and control human spinal cord tissue samples normalized to β-actin. Data are presented as mean ± SEM, * P < 0.05 versus control by unpaired two tailed t-test. Control spinal cord had many large motor neurons, whereas ALS spinal cord only had few shrunken motor neurons (top panel) (B). ISG15 staining was very weak in control spinal cord ventral horn but strong in ALS spinal cord ventral horn (bottom panel) (B). Inset shows ISG15 positive reactive astrocyte in ALS sample. Bar: 20 μm.