Table 3.
Correlation of ARID1A mutations and Immunoreactivity.
| Case | Tumor type | Nucleotide change (allele one) | Nucleotide change (allele two) | Amino Acid | Mutation type | ARID1A immunoreactivity |
|---|---|---|---|---|---|---|
| UEM-1 | Uterine EMCA | 6393delC | 5553insG | frameshift | ins/del | negative |
| UEM-2 | Uterine EMCA | 2352_2353insG | wild-type | frameshift | ins/del | diffusely positive |
| UEM-3 | Uterine EMCA | 5701G>T | wild-type | 1901G>X | nonsense | clonal loss; 20% negative |
| UEM-4 | Uterine EMCA | 1010delG | wild-type | frameshift | ins/del | negative |
| UEM-5 | Uterine EMCA | 6298C>T | 1996_2000delATTTC | 2100Q>X | nonsense | clonal loss; 50% negative |
| UEM-6 | Uterine EMCA | 3211delA | wild-type | frameshift | ins/del | clonal and mixed; 50% neg |
| UEM-7 | Uterine EMCA | 4683_4684insC | wild-type | frameshift | ins/del | clonal; 20% negative |
| UEM-8 | Uterine EMCA | 6446_6447insA | 6446_6447insA | frameshift | ins/del | negative |
| UEM-9 | Uterine EMCA | 2023_2032delAATCCAGCTC | wild-type | frameshift | ins/del | negative |
| UEM-10 | Uterine EMCA | 2368C>T | wild-type | 790Q>X | nonsense | negative |
| UEM-11 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | mixed; 10% negative |
| UEM-12 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | diffusely but weakly positive |
| UEM-13 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | mixed; 10% negative |
| UEM-14 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | negative |
| UEM-15 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | diffusely positive |
| UEM-16 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | negative |
| UEM-17 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | diffusely but weakly positive |
| UEM-18 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | diffusely positive |
| UEM-19 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | mixed; 20% negative |
| UEM-20 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | diffusely positive |
| UEM-21 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | mixed; 20% negative |
| UEM-22 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | diffusely positive |
| UEM-23 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | n/a |
| UEM-24 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | n/a |
| UEM-25 | Uterine EMCA | wild-type | wild-type | wild-type | wild-type | n/a |
| SMBT-1 | Seromucinous BT | 3216delA (homo) | 3216delA (homo) | frameshift | ins/del | negative |
| SMBT-2 | Seromucinous BT | 2165_2171delACCAGAT (homo) | 2165_2171delACCAG AT (homo) | frameshift | ins/del | negative |
| OVEM | Ovarian EMCA | Exon20 5′ intron1G>T (homo) | Exon20 5′ intron1G>T (homo) | frameshift | splicing | negative |
| OVCC | Ovarian CC | 4247insCAGC | 6026_6052del | frameshift | ins/del | negative |