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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Cancer Res. 2011 Jan 1;71(1):106–115. doi: 10.1158/0008-5472.CAN-10-2732

Figure 1. Overall Survival and Disease-Specific Survival after CI.

Figure 1

Kaplan-Meier survival curves were used to depict overall survival, solid tumor free survival, and hematologic disease free survival in WT and Nf1 mutant mice. Log-rank tests were used to test for differences between survival curves. The latency to death was measured from the date of the last radiation fraction. A and B. WT and Nf1 mutant mice had decreased survival after CI. C and D. Kaplan-Meier cause-specific survival curves were generated to reflect death due to hematologic malignancies or solid tumors. Nf1+/− mice exposed to 15 Gy CI were significantly more likely to die with hematologic disease than those that were unirradiated or exposed to 30 Gy CI (HR 4.151, 95% CI: 0.9081–18.971, p=0.0465). D. Nf1+/− mice exposed to 30 Gy CI were significantly more likely to die of solid tumors than mice that were unirradiated or exposed to 15 Gy CI (HR 1.659, 95% CI: 0.3037 – 9.058, p=0.04).