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. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Nat Struct Mol Biol. 2011 Mar 6;18(4):437–442. doi: 10.1038/nsmb.2002

Figure 5. The “wedge” formed by the CDR loops of MCS2.

Figure 5

(A) A group of bulky side-chain residues within CDRH-3 of the sAB (green sticks) form the wedge structure, which interacts with a region within MBP (blue) that is only exposed in the closed, maltose-bound conformation. (B) Sequence of the CDR loops of MCS2. Bold letters indicate residues that interact with the MBP molecule. (C) An overlay of the MCS2-MBP complex with the open form of MBP (purple, PDB code: 1OMP 12) indicates that the apo form of MBP clashes with the sAB CDR loops.