Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The HRE influences A1899 binding. A, the sequence of the HREs of TASK-1 and TASK-3 differ in one amino acid (VLRF(M/L)T) (indicated by a box). In both channels, in-frame deletion of the HRE (bottom) leads to a massive increase in IC50 values. rTASK, rat TASK. B, dose-response curves of A1899 on human TASK-1 WT (■) and an M247L (▴) mutant.
