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IC50 values of A1899 for different human potassium channels
Values were determined in Xenopus oocytes (n = 3–12) or when indicated in CHO cells (n = 3–12). TRAAK, TWIK-related arachidonic-acid-stimulated K+ channel.
| Channel | IC50 |
|---|---|
| μm | |
| TASK-1 | 0.035 ± 0.003 |
| TASK-3 | 0.318 ± 0.030 |
| TASK-1 CHO | 0.007 ± 0.001 |
| TASK-3 CHO | 0.070 ± 0.009 |
| TASK-2 | 12.0 ± 2.2 |
| TASK-4 | 8.1 ± 2.3 |
| TREK-1 | 23.8 ± 1.8 |
| TREK-2 | 8.4 ± 1.1 |
| TRAAK | >20 |
| THIK-1 | 2.2 ± 0.2 |
| TRESK | 0.9 ± 0.1 |
| Kv1.1 | 2.7 ± 0.3 |
