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Vipirinin inhibits HIV-1 infection of human macrophages. Relative infection efficiency was estimated from the activity of the luciferase encoded in the viral genome. Activities were measured 6 days after infection of HIV-1 reporter viruses with wild-type (closed symbols) or truncated (filled symbols) Vpr. Activities from cells treated with each compound are shown in relative values to that of cells infected with wild-type Vpr containing viruses without compounds.
