TABLE 2.
Electrical parameters for acid secretion experiments
Shown are the effects of forskolin (10−5 m) on the PD, Isc, and Rt of gastric mucosae from Kir4.1+/+, Kir4.1+/−, and Kir4.1−/− mice before and 30 min after forskolin stimulation. No significant difference in PD, Isc, and Rt was observed at these time points in Kir4.1+/+, Kir4.1+/−, and Kir4.1−/− mice (p < 0.05). The values were calculated from six out of eight experiments with Kir4.1−/− mucosa and a matched Kir4.1+/+ and Kir+/− mucosa for each Kir−/− mucosa. Values are expressed as means ± S.E.
| PD |
Isc |
Rt |
||||
|---|---|---|---|---|---|---|
| Basal | 30 min post-forskolin | Basal | 30 min post-forskolin | Basal | 30 min post-forskolin | |
| mV | μeq·cm−2·h−1 | ω·cm2 | ||||
| Kir4.1+/+ (n = 6) | 22.59 ± 1.25 | 26.28 ± 1.69 | 10.40 ± 1.00 | 12.28 ± 1.37 | 98.28 ± 5.89 | 82.40 ± 7.39 |
| Kir4.1+/− (n = 6) | 23.39 ± 1.67 | 27.08 ± 2.19 | 10.62 ± 1.05 | 13.70 ± 1.80 | 100.40 ± 7.35 | 94.31 ± 6.70 |
| Kir4.1−/− (n = 6) | 21.39 ± 1.65 | 26.41 ± 2.40 | 8.83 ± 0.91 | 11.56 ± 1.21 | 106.07 ± 5.00 | 94.84 ± 5.13 |