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Model of DENV modulation of the unfolded protein response. Schematic diagram illustrating the effects of DENV-2 infection on the UPR according to the results presented in this study, demonstrating the time-dependent activation of the three branches of the UPR and showing that induction of the UPR does not lead to the induction of apoptosis. Arrows indicate activation or induction by DENV-2, and T-lines and X indicate inhibition as a result of DENV infection.
