FIGURE 7.

Proposed model for the Myo5a/Rab3A interaction on SVs. This model integrates the SV abundant membrane proteins Rab3A and Rabphilin3A and illustrates a possible interaction of the Myo5a tail-domain with the SV. A, active or GTP-bound form of Rab3A builds a complex with Rabphilin3A on the surface of SV that binds directly to the globular tail domain of Myo5a. B, Rab3A dissociates from Myo5a tail and Rabphilin3A after GTP hydrolysis (1) and binds to RabGDI in its inactive or GDP-bound form (2) until GDP/GTP exchange.