Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Feb 23;286(16):14362–14372. doi: 10.1074/jbc.M110.214189

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 8. — A, summary of mutagenesis analysis of cavities A and B. Based on the IFA results, the replication levels of WT and mutants RNAs are categorized into strong (++++), medium (++), weak (+/−), and nonreplicative (−). B, crystal structure of DENV RdRp showing residues Thr-806, Glu-807, Asp-808, Met-809 (all in yellow), and Lys-756 (in red) from cavity A. The priming loop is shown in yellow. The GDD active site of RdRp is shown in pink. C, crystal structure of DENV RdRp showing residues Leu-328, Lys-330, Trp-859, and Ile-863 (all in red) from cavity B. Amino acid Gly-840, a compensatory mutation for K330A, is labeled in blue. The illustrations for B and C were prepared using PyMOL.