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. 2011 Feb 15;286(16):14516–14530. doi: 10.1074/jbc.M110.157149

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Genetic interactions of mms21Δsl with mutants defective in replication stress and DNA damage checkpoint pathways. A, the mms21Δsl mutant cells are HU-sensitive. WT (YPH499) and mms21Δsl (SLY792) strains were grown to midlog phase, serially diluted, spotted onto a YAPD plate containing 150 mm HU, and incubated at 23 °C for 5 days. B, genetic interaction of mms21Δsl with checkpoint-defective mutants mrc1 and rad9. WT (Y1134), mrc1 (Y1127), mms21Δsl (SLY1523), mrc1 mms21Δsl (SLY1516), rad9 (Y2297), and rad9 mms21Δsl (SLY1526) strains were grown to midlog phase, serially diluted, spotted on adenine supplemented YPD plates or YAPD plates having the indicated concentrations of MMS and HU, and incubated for 3 days. C, genetic interaction of mms21Δsl with DNA damage checkpoint-defective mutants rad9 and rad24. WT (Y1134), mms21Δsl (SLY1523), rad9 (Y2297), rad9 mms21Δsl (SLY1526), rad24 (SLY1534), and rad24 mms21Δsl (SLY1543) strains were grown to midlog phase and analyzed for MMS and HU sensitivity.