FIGURE 7.

Nampt regulates lipid metabolism in vivo. A–C, control and LTKO mice (n = 4) were injected with GFP- or Nampt-overexpressing adenoviruses via the tail vein, and Nampt protein, NAD⁺, and TG levels were analyzed in the liver of those mice 7 days postinjection. D–F, wild-type mice (n = 4) were injected with adenoviruses expressing GFP and Nampt shRNAs, and liver Nampt protein, NAD⁺, and TG levels were analyzed 7 days postinfection. G–I, Nampt-expressing adenoviruses were injected into mice that were deficient in hepatic Sirt1 (n = 4), and Nampt protein, NAD⁺, and TG levels in the livers were analyzed 7 days postinjection. * indicates significance with p < 0.05 between control and experimental groups. Error bars indicate S.E.