Figure 1.

(a) Chemical structure of naproxen. Methoxy (G2) and carboxylate (G3) groups are linked to the central hydrophobic naphthalene ring (G1). Carbon and oxygen atoms are in gray and red (in online version). (b) The WT sequence of A${\beta }_{10-40}$ peptide and the allocation of the N- and C-terminals (Nt and Ct). In the mutant sequence the order of amino acids is reversed. (c) Typical structure of Aβ dimer coincubated with naproxen ligands at 360 K. Aβ Nt and Ct terminals are shown in red and yellow, respectively (in online version). Naproxen ligands bind with higher affinity to the N-terminal, which is also the primary dimer aggregation interface.