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Consensus sequence around the conserved HG motif in the cytosolic amino-terminus of ENaC/Deg subunits. The sequences shown for α-, β-, and γ-ENaC subunits are absolutely conserved among ENaC orthologs but not ENaC/Deg paralogs. Examples of paralogs that contain the different amino acids at −3, −2, and +1 reported to date are shown below. Numbering for α-mENaC.
