Figure 3.

Kaplan-Meier curves showing the effect of β-arrestin-1 on RFS. A: In cohort I, only stromal expression (right panel) had an effect on overall survival. B: In the subgroup of untreated control patients of cohort II, negative or high expression of stromal β-arrestin-1 was associated with a shorter RFS, compared with low or moderate expression (right panel). There was a trend indicating that also high tumor cell expression was linked to a reduced RFS in cohort II (left panel). C: ERα-positive patients with tumors of low or moderate stromal β-arrestin-1 expression (right panel) did not benefit from tamoxifen treatment, in contrast to patients with tumors exhibiting negative or high expression (left panel).