Figure 1.

Peroxisomes, peroxisomal pathways, and white matter disease. Morphology of catalase-stained liver peroxisomes (A); β-oxidative pathway for degradation of very-long-chain fatty acids, hydrogen peroxide generation, and detoxification by catalase (B); and initial reactions of plasmalogens synthesis in peroxisomes (C). Course of progression of demyelination in the occipital region (arrows) of a brain affected with the severe form of adrenoleukodystrophy, as seen by magnetic resonance imaging. Images were obtained at patient age 7 (a), age 8 (b), and age 9 (c).³⁰