Table 3.

Rat Brain Glial Cell Survival to Mothers’ Systemic Exposure to Bacterial LPS and Protection by NAC Pretreatment

Groups	Primary Cell Culture Developing Oligodendrocytes		Astrocytes (GFAP+)	Neurons (ENOLASE+)
CTL	17.54 ± 0.02 ***	21.76 ± 0.02 ***	39.72 ± 0.23	13.71 ± 0.12
LPS	6.73 ± 0.01	4.06 ± 0.01	46.47 ± 0.46	12.57 ± 0.001
NAC + LPS	18.14 ± 0.02 ***	21.38 ± 0.01 ***	34.60 ± 0.26	14.93 ± 0.23

^***P < .001 versus LPS group. Rat brain glial cell survival in the fetal brain at embryonic day 20, 48 hours postbacterial LPS systemic exposure to pregnant mothers (embryonic day 18) and protection by NAC pretreatment (2 hours prior to LPS administration).

Abbreviations: CTL, control; GFAP⁺, glial fibrillary acidic protein (cellular marker for astrocytes); LPS, lipopolysaccharide; NAC, N-acetylcysteine; O4⁺; O1⁺, cellular markers for oligodendrocytes precursor cells. Modified from reference ⁷⁰.