Table 2.
Endpoint parameter | Baseline | Group 1 (sulindac) | Group 2 (VSL#3 + inulin) | Group 3 (sulindac + VSL#3 + inulin) |
---|---|---|---|---|
Proliferationa | 0.51 (0.35–0.80) | 0.47 (0.15–0.65) | 0.42 (0.39–0.55) | 0.60 (0.39–0.75) |
GSTa | 376 (271–606) | 421 (334–523) | 382 (328–563) | 399 (229–518) |
Cytotoxicitya | 54.2 (11.7–325) | 95.0 (20.8–150) | 50.8 (1.5–237) | 95.0 (20.0–177) |
SCFAa | 77.2 (42.1–118) | 71.9 (51.4–121) | 67.8 (31.2–138) | 77.8 (42.1–102) |
Fecal pHa | 5.92 (4.90–7.37) | 5.48 (4.82–7.22) | 6.05 (4.82–6.96) | 5.53 (4.86–6.59) |
Proliferation is given as the ratio labeled/unlabeled cells. GST activity is given in nanomoles per minute milligram protein. Cytotoxicity is the dilution factor at which 50% of the cells have died. SCFA is given in millimoles per liter. Fecal pH is given in pH units
aValues are given as median (range)