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Model for Regulation of REV Dimerization by the MEKHLA Domain.
The MEKHLA domain prevents REV dimerization in a steric fashion. An unknown mechanism would then recognize the sequence of the MEKHLA domain and relieve the inhibition. This molecular switch precedes REV homodimerization and heterodimerization with other HD-ZIP III proteins and interaction with ZPR proteins.
[See online article for color version of this figure.]
