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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Immunol Rev. 2011 May;241(1):180–205. doi: 10.1111/j.1600-065X.2011.01011.x

Fig. 1. Biochemical and transcriptional effects of the CD28 signaling pathways.

Fig. 1

Summary of biochemical signaling events downstream of the proximal and distal CD28 motifs that can modulate the T-cell transcription pattern after costimulation. Among the different mechanisms, we can distinguish a direct effect on gene expression by regulation of transcription factors or an indirect effect through increases in mRNA stability.